48 cards where the cards aren’t reprints and the card is tagged “weaker-in-singleton-formats”

Maelstrom Pulse (Alara Reborn #92)
Detention Sphere (Return to Ravnica #155)
Dragonlord Kolaghan (Dragons of Tarkir #218)
Declaration in Stone (Shadows over Innistrad #12)
Izzet Staticaster (Return to Ravnica #173)
Leyline of Singularity (Guildpact #29)
Deputy of Detention (Ravnica Allegiance #165)
Korlash, Heir to Blackblade (Future Sight #87)
Circu, Dimir Lobotomist (Ravnica: City of Guilds #196)
Baru, Fist of Krosa (Future Sight #142)
Nantuko Shrine (Odyssey #256)
Ashiok's Erasure (Theros Beyond Death #43)
Charmed Stray (War of the Spark #8)
Ixalan's Binding (Ixalan #17)
Homing Lightning (Gatecrash #96)
Gigantiform (Zendikar #162)
Extirpate (Planar Chaos #71)
Oriss, Samite Guardian (Future Sight #28)
Exclusion Ritual (New Phyrexia #10)
Aven Shrine (Odyssey #9)
Twinning Glass (Lorwyn #264)
Eye of Singularity (Visions #4)
Eradicate (Urza's Destiny #60)
Skoa, Embermage (Modern Horizons 3 #138)
Cranial Extraction (Champions of Kamigawa #105)
Deicide (Journey into Nyx #7)
Legion's End (Core Set 2020 #106)
Linessa, Zephyr Mage (Future Sight #51)
Unmoored Ego (Guilds of Ravnica #212)
Scalpelexis (Judgment #50)
Embermage Goblin (Onslaught #200)
Demigod of Revenge (Shadowmoor #183)
Bazaar of Wonders (Mirage #55)
Counterbore (Shadowmoor #33)
Dispossess (Amonkhet #86)
Frostpyre Arcanist (Kaldheim #58)
Desperate Research (Invasion #100)
Crumble to Dust (Battle for Zendikar #128)
Jester's Scepter (Coldsnap #137)
Haunting Echoes (Odyssey #142)
Chrome Replicator (Core Set 2021 #229)
Tarox Bladewing (Future Sight #123)
Reap Intellect (Dragon's Maze #95)
Mindreaver (Born of the Gods #44)
Moratorium Stone (Guildpact #154)
Ivory Guardians (Legends #23)
Cylian Sunsinger (Conflux #80)
Sixth Stage of Magic Design (Unknown Event #RW03h)

It is the moment of discovery, the triumph of the mind, and the end of these results.