56 cards where the cards aren’t reprints and the set is “c16”

Akiri, Line-Slinger (Commander 2016 #26)
Ancient Excavation (Commander 2016 #27)
Armory Automaton (Commander 2016 #51)
Ash Barrens (Commander 2016 #56)
Atraxa, Praetors' Voice (Commander 2016 #28)
Benefactor's Draught (Commander 2016 #21)
Boompile (Commander 2016 #52)
Breya, Etherium Shaper (Commander 2016 #29)
Bruse Tarl, Boorish Herder (Commander 2016 #30)
Charging Cinderhorn (Commander 2016 #16)
Coastal Breach (Commander 2016 #6)
Conqueror's Flail (Commander 2016 #53)
Cruel Entertainment (Commander 2016 #11)
Crystalline Crawler (Commander 2016 #54)
Curse of Vengeance (Commander 2016 #12)
Curtains' Call (Commander 2016 #13)
Deepglow Skate (Commander 2016 #7)
Divergent Transformations (Commander 2016 #17)
Duelist's Heritage (Commander 2016 #1)
Entrapment Maneuver (Commander 2016 #2)
Evolutionary Escalation (Commander 2016 #22)
Faerie Artisans (Commander 2016 #8)
Frenzied Fugue (Commander 2016 #18)
Goblin Spymaster (Commander 2016 #19)
Grave Upheaval (Commander 2016 #31)
Grip of Phyresis (Commander 2016 #9)
Ikra Shidiqi, the Usurper (Commander 2016 #32)
Ishai, Ojutai Dragonspeaker (Commander 2016 #33)
Kraum, Ludevic's Opus (Commander 2016 #34)
Kydele, Chosen of Kruphix (Commander 2016 #35)
Kynaios and Tiro of Meletis (Commander 2016 #36)
Ludevic, Necro-Alchemist (Commander 2016 #37)
Magus of the Will (Commander 2016 #14)
Manifold Insights (Commander 2016 #10)
Migratory Route (Commander 2016 #38)
Orzhov Advokist (Commander 2016 #3)
Parting Thoughts (Commander 2016 #15)
Primeval Protector (Commander 2016 #23)
Prismatic Geoscope (Commander 2016 #55)
Ravos, Soultender (Commander 2016 #39)
Reyhan, Last of the Abzan (Commander 2016 #40)
Runehorn Hellkite (Commander 2016 #20)
Saskia the Unyielding (Commander 2016 #41)
Seeds of Renewal (Commander 2016 #24)
Selfless Squire (Commander 2016 #4)
Sidar Kondo of Jamuraa (Commander 2016 #42)
Silas Renn, Seeker Adept (Commander 2016 #43)
Stonehoof Chieftain (Commander 2016 #25)
Sublime Exhalation (Commander 2016 #5)
Sylvan Reclamation (Commander 2016 #44)
Tana, the Bloodsower (Commander 2016 #45)
Thrasios, Triton Hero (Commander 2016 #46)
Treacherous Terrain (Commander 2016 #47)
Tymna the Weaver (Commander 2016 #48)
Vial Smasher the Fierce (Commander 2016 #49)
Yidris, Maelstrom Wielder (Commander 2016 #50)

Though this query has ended, its relics still slumber in New Argive.