22 cards where the cards aren’t reprints and the mana cost is greater than or equal to {3}{R}{G}{W}

Zacama, Primal Calamity (Rivals of Ixalan #174)
Gishath, Sun's Avatar (Ixalan #222)
The Ur-Dragon (Commander 2017 #48)
Conflux (Conflux #102)
Phabine, Boss's Confidant (New Capenna Commander #9)
Primeval Spawn (Dominaria United Commander #13)
Yuma, Proud Protector (Outlaws of Thunder Junction Commander #4)
Havi, the All-Father (Assassin's Creed #56)
Eivor, Wolf-Kissed (Assassin's Creed #54)
Rith, the Awakener (Invasion #267)
Godsire (Shards of Alara #170)
Cabaretti Confluence (New Capenna Commander #69)
Ultra Magnus, Tactician // Ultra Magnus, Armored Carrier (Transformers #15)
Ultra Magnus, Tactician // Ultra Magnus, Armored Carrier (Transformers #15)
Palladia-Mors, the Ruiner (Core Set 2019 #219)
Annie Flash, the Veteran (Outlaws of Thunder Junction #190)
Meeting of the Five (Streets of New Capenna #202)
Meglonoth (Conflux #118)
Realm Razer (Shards of Alara #187)
Hazezon Tamar (Legends #230)
Johan (Legends #236)
Coalition Victory (Invasion #241)
Who // What // When // Where // Why (Unhinged #120)

Though this query has ended, its relics still slumber in New Argive.