22 cards where the text includes “destroy target” and the card types include “instant” and the mana cost is greater than or equal to {1}{B} and the mana value = 2

Assassin's Blade (Portal #80)
Bitter Triumph (The Lost Caverns of Ixalan #91)
Cast Down (Commander Legends: Battle for Baldur's Gate #119)
Cradle to Grave (Planar Chaos #67)
Cruel Cut (Arena Beginner Set #47)
Doom Blade (Iconic Masters #87)
Easy Prey (Ikoria: Lair of Behemoths #87)
Eliminate (Core Set 2021 #97)
Feast of Dreams (Journey into Nyx #69)
Feed the Cycle (Bloomburrow #94)
Go for the Throat (March of the Machine Commander #250)
Heartless Act (Commander Masters #166)
Hero's Demise (Betrayers of Kamigawa #68)
Infernal Grasp (Duskmourn: House of Horror Commander #143)
Long Goodbye (Murders at Karlov Manor #92)
Noxious Grasp (Core Set 2020 #110)
Power Word Kill (Adventures in the Forgotten Realms #114)
Shoot the Sheriff (Outlaws of Thunder Junction #106)
Smother (Duel Decks: Zendikar vs. Eldrazi #57)
Soul Rend (Mirage #144)
Terror (Dominaria Remastered #103)
Ultimate Price (Ravnica Remastered #95)

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