53 cards where the cards aren’t reprints and the card is tagged “removal-permanent-destroy”

Beast Within (New Phyrexia #103)
Generous Gift (Modern Horizons #11)
Assassin's Trophy (Guilds of Ravnica #152)
Red Elemental Blast (Limited Edition Alpha #169)
Pyroblast (Ice Age #213)
Ugin, the Ineffable (War of the Spark #2)
Ulamog, the Infinite Gyre (Rise of the Eldrazi #12)
Vindicate (Apocalypse #126)
Wild Magic Surge (Commander Legends: Battle for Baldur's Gate #206)
Staff of Compleation (Phyrexia: All Will Be One #242)
Argentum Armor (Scars of Mirrodin #137)
Spine of Ish Sah (Mirrodin Besieged #136)
Rise of the Eldrazi (Commander Masters #716)
Unstable Obelisk (Commander 2014 #58)
Karmic Justice (Odyssey #26)
Null Elemental Blast (Modern Horizons 3 #12)
Necrotic Sliver (Planar Chaos #159)
Angel of Despair (Guildpact #101)
Alpha Deathclaw (Fallout #91)
Lux Cannon (Scars of Mirrodin #173)
Reaper King (Shadowmoor #260)
Invasion of Alara // Awaken the Maelstrom (March of the Machine #230)
Invasion of Alara // Awaken the Maelstrom (March of the Machine #230)
Blue Elemental Blast (Limited Edition Alpha #49)
Clay Golem (Forgotten Realms Commander #58)
Despotic Scepter (Ice Age #316)
Hydroblast (Ice Age #72)
Commander Sofia Daguerre (Fallout #15)
Jaya Ballard, Task Mage (Time Spiral #166)
The Most Dangerous Gamer (Unfinity #174)
Violent Ultimatum (Shards of Alara #206)
Universal Solvent (Aether Revolt #178)
Desert Twister (Arabian Nights #46)
Goblin Firebomb (The Brothers' War #235)
Pentarch Paladin (Time Spiral #32)
Active Volcano (Legends #130)
Teferi's Response (Invasion #78)
Flash Flood (Legends #57)
Eye of Doom (Commander 2013 #243)
Northern Paladin (Limited Edition Alpha #29)
Southern Paladin (Weatherlight #27)
Pure // Simple (Dissension #154)
Tornado (Alliances #101)
Saltblast (Planar Chaos #15)
Venomous Vines (Judgment #136)
Ass Whuppin' (Unhinged #117)
Chaos Confetti (Unglued #72)
Chaos Orb (Limited Edition Alpha #235)
Event Horizon (Unknown Event #PLA015)
Herald of Vengeance (Alchemy: New Capenna #2)
Jalum Grifter (Unglued #47)
Landfill (Unglued #49)
Lexivore (Unglued #7)
Pointy Finger of Doom (Unhinged #126)

In the blink of an eye, they strode from deep snow to the end of this search.