22 cards where the cards aren’t reprints and the mana cost is greater than or equal to {2}{R}{W}{B}

The Ur-Dragon (Commander 2017 #48)
Tiamat (Adventures in the Forgotten Realms #235)
Edgar Markov (Commander 2017 #36)
Conflux (Conflux #102)
Unite the Coalition (Dominaria United Commander #15)
Piru, the Volatile (Modern Horizons 2 #207)
Ankle Shanker (Khans of Tarkir #164)
Primeval Spawn (Dominaria United Commander #13)
Syr Gwyn, Hero of Ashvale (Throne of Eldraine #330)
Tariel, Reckoner of Souls (Commander 2011 #229)
Zurgo Helmsmasher (Khans of Tarkir #214)
Megatron, Tyrant // Megatron, Destructive Force (Transformers #12)
Megatron, Tyrant // Megatron, Destructive Force (Transformers #12)
Kroxa and Kunoros (March of the Machine #245)
Licia, Sanguine Tribune (Commander 2017 #40)
Malik, Grim Manipulator (Secret Lair Drop #147)
Oros, the Avenger (Planar Chaos #161)
Meeting of the Five (Streets of New Capenna #202)
Offspring's Revenge (Ikoria: Lair of Behemoths #198)
Ponyback Brigade (Khans of Tarkir #191)
Mardu Roughrider (Khans of Tarkir #187)
Coalition Victory (Invasion #241)
Who // What // When // Where // Why (Unhinged #120)

This search is finished. Now the real work can begin.